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Literature summary extracted from

  • Terret, M.; Jallepalli, P.V.
    Meiosis: separase strikes twice (2006), Nat. Cell Biol., 8, 910-911.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.49 molecular biology in Saccharomyces cerevisiae separase it is shown that separase is implicated in a second non-proteolytic pathway: separsae is essential for the activation of Cdc14 phosphatase and thus a broad programme of late mitotic events culminating in mitotic exit and cell division Saccharomyces cerevisiae
3.4.22.49 molecular biology separse is not only required for chromosome segregation but also for meiotic exit Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.49 additional information clear evidence for a non-proteolytic function of separase is provided: by separase gene deletion in mouse oocytes it is shown that separase null-oocytes are unable to either destroy chesin along chromosome arms or segregate homologous chromosomes and these oocytes are unable to complete cell division. Microinjection of wild-type separase mRNA in separase null-oocytes restores normal homologue disjunction and polar body extrusion Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Mus musculus
-
-
-
3.4.22.49 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.49 oocyte
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.49 separase
-
 Mus musculus
3.4.22.49 separase
-
 Saccharomyces cerevisiae